Network analysis uncovers putative genes affecting resistance to tick infestation in Braford cattle skin.

ABSTRACT:

Background

Genetic resistance in cattle is considered a suitable way to control tick burden and its consequent losses for livestock production. Exploring tick-resistant (R) and tick-susceptible (S) hosts, we investigated the genetic mechanisms underlying the variation of Braford resistance to tick infestation. Skin biopsies from four-times-artificially infested R (n = 20) and S (n = 19) hosts, obtained before the first and 24 h after the fourth tick infestation were submitted to RNA-Sequencing. Differential gene expression, functional enrichment, and network analysis were performed to identify genetic pathways and transcription factors (TFs) affecting host resistance.

Results

Intergroup comparisons of hosts before (Rpre vs. Spre) and after (Rpost vs. Spost) tick infestation

SUBMITTER: More DD 

PROVIDER: S-EPMC6923859 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature