G6PD genetic variations in neonatal Hyperbilirubinemia in Indonesian Deutromalay population.

ABSTRACT:

Background

Neonatal jaundice is a common finding in newborns in Asia, including Indonesia. In some cases, the serum total bilirubin levels exceeds the 95th percentile for hours of life (neonatal hyperbilirubinemia). Severe neonatal hyperbilirubinemia (NH) could lead to kernicterus and neonatal death. Glucose-6-Phosphage Dehydrogenase (G6PD) genetic variations and deficiency have been reported in several studies to be associated with NH. This study aimed to analyze the G6PD genetic variations and its activity in neonates with and without hyperbilirubinemia in the Deutromalay Indonesian population.

Methods

Deoxyribose Nucleic Acid (DNA) was isolated from peripheral blood of 116 and 115 healthy term neonates with and without hyperbilirubinemia. All infants underwent the followi

SUBMITTER: Wisnumurti DA 

PROVIDER: S-EPMC6923888 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature