RAB6C is an independent prognostic factor of estrogen receptor-positive/progesterone receptor-negative breast cancer.

ABSTRACT: The majority of breast cancer tumors are estrogen receptor-positive (ER+) and can be treated with endocrine therapy. However, certain patients may exhibit a good prognosis without systemic treatment. The aim of the present study was to identify novel prognostic factors for patients with ER+ breast cancer tumors using gene copy data, and to investigate if these factors have prognostic value in subgroups categorized by progesterone receptor status (PR). Public data, including the whole genome gene copy data of 199 systemically untreated patients with ER+ tumors, were utilized in the present study. To assess prognostic value, patients were divided into two groups using the median gene copy number as a cut-off for the SNPs that were the most variable. One SNP was identified, which indicated th

SUBMITTER: Fohlin H 

PROVIDER: S-EPMC6923975 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature