Targeted therapy in pulmonary veno-occlusive disease: time for a rethink?

ABSTRACT:

Background

Pulmonary veno-occlusive disease (PVOD) is a rare condition with poor prognosis, and lung transplantation is recommended as the only curative therapy. The role of pulmonary arterial hypertension targeted therapy in PVOD remains controversial, and long-term effects of targeted therapy have been rarely reported. This study aims to retrospectively evaluate the role of targeted therapy in PVOD patients and the long-term outcome.

Methods

PVOD patients with good responses to targeted therapies were analyzed, and data pre- and post- targeted therapies were compared. An overview of the effects of targeted therapies on PVOD patients was also conducted.

Results

Five genetically or histologically confirmed PVOD patients received targeted therapies and showed good resp

SUBMITTER: Luo Q 

PROVIDER: S-EPMC6924010 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature