Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups.

ABSTRACT:

Purpose

With the updated World Health Organization (WHO) 2016 neuropathological diagnostic criteria, radiographic prognostic associations in lower-grade gliomas (LGG, WHO grade II and III) are undergoing re-evaluation.

Methods

We identified 316 LGG patients (151 grade II and 165 grade III) for a combined cohort from three independent databases. We analyzed the preoperative axial FLAIR, axial T2-weighted and post-gadolinium volumetric T1-weighted MR images. The molecular data collected included the status of IDH1/2, TP53, TERT promoter and ATRX mutations, in addition to 1p/19q co-deletions. In a subset of cases (n = 133), we assessed the "T2-FLAIR mismatch" sign.

Results

Gliomas were assigned to one of the three molecular groups: Group O (IDH-mutant, 1p/19q co-deleted

SUBMITTER: Juratli TA 

PROVIDER: S-EPMC6924170 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature