Cognitive Impairment and Mortality in a Population-Based Parkinson's Disease Cohort.

ABSTRACT:

Background

Parkinson's disease (PD) is a heterogeneous disorder with variability in phenotype and progression.

Objective

We describe characteristics of PD patients in the largest population-based cohort followed for progression to date, and evaluate clinical risk factors for cognitive impairment and mortality.

Methods

We collected longitudinal data using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Exam (MMSE), and Geriatric Depression Scale (GDS) in 242 new-onset PD patients followed for progression. We compared those who developed cognitive impairment (MMSE≤24) with those who did not, using t-tests, chi-square tests, and Cox proportional hazards regression. Mortality risk factors were assessed in all 360 patients enrolled at baseline.

R

SUBMITTER: Keener AM 

PROVIDER: S-EPMC6924612 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature