Murcia atrial fibrillation project II: protocol for a prospective observational study in patients with atrial fibrillation.

ABSTRACT:

Introduction

Atrial fibrillation (AF) is characterised by a high stroke risk. Vitamin K antagonists (VKAs) are the most commonly used oral anticoagulants (OACs) in Spain, but their efficacy and safety depend on the time in therapeutic range of International Normalized Ratio (INR) 2.0-3.0 over 65%-70%. Unfortunately, the difficulties of maintaining an optimal level of anticoagulation and the complications of VKAs (particularly haemorrhagic ones), frequently lead to cessation of this therapy, which has been associated with higher risk of adverse events (AEs), including ischaemic stroke. Our aims are as follows: (1) to evaluate the quality of oral anticoagulation with VKAs, the prevalence of poor quality of anticoagulation, and to identify factors predisposing to poor quality anticoag

SUBMITTER: Rivera-Caravaca JM 

PROVIDER: S-EPMC6924708 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature