Safety and efficacy of perioperative benzodiazepine administration: study protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Perioperative benzodiazepines are used because of their anxiolytic, sedative and amnestic effects. Evidence has demonstrated an association of benzodiazepines with adverse neuropsychiatric effects. Nonetheless, because of their potential benefits, perioperative benzodiazepines continue to be used routinely. We seek to evaluate the body of evidence of the risks and benefits of benzodiazepine use during the perioperative period.

Methods and analysis

We will search Cochrane CENTRAL, MEDLINE, EMBASE, PsychINFO, CINAHL and Web of Science from inception to March 2019 for randomised controlled trials (RCTs) and observational studies evaluating the administration of benzodiazepine medications as compared with all other medications (or nothing) in patients undergoing car

SUBMITTER: Spence J 

PROVIDER: S-EPMC6924818 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature