Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype.

ABSTRACT: Genes with similar roles in the cell cluster on chromosomes, thus benefiting from coordinated regulation. This allows gene function to be inferred by transferring annotations from genomic neighbors, following the guilt-by-association principle. We performed a systematic search for co-occurrence of >1000 gene functions in genomic neighborhoods across 1669 prokaryotic, 49 fungal and 80 metazoan genomes, revealing prevalent patterns that cannot be explained by clustering of functionally similar genes. It is a very common occurrence that pairs of dissimilar gene functions - corresponding to semantically distant Gene Ontology terms - are significantly co-located on chromosomes. These neighborhood associations are often as conserved across genomes as the known associations between similar functi

SUBMITTER: Mihelcic M 

PROVIDER: S-EPMC6925100 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature