A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data.

ABSTRACT: There is well-documented evidence of brain network differences between individuals with Alzheimer's disease (AD) and healthy controls (HC). To date, imaging studies investigating brain networks in these populations have typically been cross-sectional, and the reproducibility of such findings is somewhat unclear. In a novel study, we use the longitudinal ADNI data on the whole brain to jointly compute the brain network at baseline and one-year using a state of the art approach that pools information across both time points to yield distinct visit-specific networks for the AD and HC cohorts, resulting in more accurate inferences. We perform a multiscale comparison of the AD and HC networks in terms of global network metrics as well as at the more granular level of resting state networks defi

SUBMITTER: Kundu S 

PROVIDER: S-EPMC6925181 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature