Metabolomic and metallomic profile differences between Veterans and Civilians with Pulmonary Sarcoidosis.

ABSTRACT: Sarcoidosis is a disorder characterized by granulomatous inflammation of unclear etiology. In this study we evaluated whether veterans with sarcoidosis exhibited different plasma metabolomic and metallomic profiles compared with civilians with sarcoidosis. A case control study was performed on veteran and civilian patients with confirmed sarcoidosis. Proton nuclear magnetic resonance spectroscopy (¹H NMR), hydrophilic interaction liquid chromatography mass spectrometry (HILIC-MS) and inductively coupled plasma mass spectrometry (ICP-MS) were applied to quantify metabolites and metal elements in plasma samples. Our results revealed that the veterans with sarcoidosis significantly differed from civilians, according to metabolic and metallomics profiles. Moreover, the results showe

SUBMITTER: Banoei MM 

PROVIDER: S-EPMC6925242 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature