Ontology highlight
ABSTRACT:
SUBMITTER: Murphy AJ
PROVIDER: S-EPMC6925259 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nature communications 20191220 1
The lack of model systems has limited the preclinical discovery and testing of therapies for Wilms tumor (WT) patients who have poor outcomes. Herein, we establish 45 heterotopic WT patient-derived xenografts (WTPDX) in CB17 scid<sup>-/-</sup> mice that capture the biological heterogeneity of Wilms tumor (WT). Among these 45 total WTPDX, 6 from patients with diffuse anaplastic tumors, 9 from patients who experienced disease relapse, and 13 from patients with bilateral disease are included. Early ...[more]