R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.

ABSTRACT: While the opportunities available for targeting RNA with small molecules have been widely appreciated, the challenges associated with achieving specific RNA recognition in biological systems have hindered progress and prevented many researchers from entering the field. To facilitate the discovery of RNA-targeted chemical probes and their subsequent applications, we curated the RNA-targeted BIoactive ligaNd Database (R-BIND). This collection contains an array of information on reported chemical probes that target non-rRNA and have biological activity, and analysis has led to the discovery of RNA-privileged properties. Herein, we developed an online platform to make this information freely available to the community, offering search options, a suite of tools for probe development, and an upd

SUBMITTER: Morgan BS 

PROVIDER: S-EPMC6925312 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature