Atypical Functional Connectivity in Tourette Syndrome Differs Between Children and Adults.

ABSTRACT:

Background

Tourette syndrome (TS) is a neuropsychiatric disorder with symptomatology that typically changes over development. Whether and how brain function in TS also differs across development has been largely understudied. Here, we used functional connectivity magnetic resonance imaging to examine whole-brain functional networks in children and adults with TS.

Methods

Multivariate classification methods were used to find patterns among functional connections that distinguish individuals with TS from control subjects separately for children and adults (N = 202). We tested whether the patterns of connections that classify diagnosis in one age group (e.g., children) could classify diagnosis in another age group (e.g., adults). We also tested whether the developmental traject

SUBMITTER: Nielsen AN 

PROVIDER: S-EPMC6925331 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature