Hyperandrogenemia is Common in Asymptomatic Women and is Associated with Increased Metabolic Risk.

ABSTRACT:

Objective

Women with metabolic syndrome (MetS) have higher endogenous testosterone (T) levels than unaffected women. This study investigated whether hyperandrogenemia (HA) was a marker for increased cardiometabolic risk in reproductively normal premenopausal women.

Methods

Reproductive hormones and metabolic parameters were assessed in 198 women with regular menses and no clinical hyperandrogenism (eumenorrheic [EM]). Hyperandrogenic EM women were compared with 110 women with NIH criteria polycystic ovary syndrome.

Results

Twenty-two percent of EM women had HA. Levels of non-sex hormone-binding globulin (SHBG)-bound T were elevated in 68% of women, total T levels were elevated in 43% of women, and dehydroepiandrosterone sulfate levels were elevated in 30% of women. Th

SUBMITTER: Torchen LC 

PROVIDER: S-EPMC6925332 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature