Effect of Hemodynamic Changes in Plasma Propofol Concentrations Associated with Knee-Chest Position in Spinal Surgery: A Prospective Study.

ABSTRACT:

Background

Anesthesia induction and maintenance with propofol can be guided by target-controlled infusion (TCI) systems using pharmacokinetic (Pk) models. Physiological variables, such as changes in cardiac output (CO), can influence propofol pharmacokinetics. Knee-chest (KC) surgical positioning can result in CO changes.

Objectives

This study aimed to evaluate the relationship between propofol plasma concentration prediction and CO changes after induction and KC positioning.

Methods

This two-phase prospective cohort study included 20 patients scheduled for spinal surgery. Two different TCI anesthesia protocols were administered after induction. In phase I (n = 9), the loss of consciousness (LOC) concentration was set as the propofol target concentration and CO change

SUBMITTER: Chalo D 

PROVIDER: S-EPMC6925539 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature