Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics.

ABSTRACT:

Introduction

Although the relationship between APOE and Alzheimer's disease (AD) is well established in populations of European descent, the effects of APOE and ancestry on AD risk in diverse populations is not well understood.

Methods

Logistic mixed model regression and survival analyses were performed in a sample of 3067 Caribbean Hispanics and 3028 individuals of European descent to assess the effects of APOE genotype, local ancestry, and genome-wide ancestry on AD risk and age at onset.

Results

Among the Caribbean Hispanics, individuals with African-derived ancestry at APOE had 39% lower odds of AD than individuals with European-derived APOE, after adjusting for APOE genotype, age, and genome-wide ancestry. While APOE E2 and E4 effects on AD risk and age at onset

SUBMITTER: Blue EE 

PROVIDER: S-EPMC6925639 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature