Individualized clinical management of patients at risk for Alzheimer's dementia.

ABSTRACT:

Introduction

Multidomain intervention for Alzheimer's disease (AD) risk reduction is an emerging therapeutic paradigm.

Methods

Patients were prescribed individually tailored interventions (education/pharmacologic/nonpharmacologic) and rated on compliance. Normal cognition/subjective cognitive decline/preclinical AD was classified as Prevention. Mild cognitive impairment due to AD/mild-AD was classified as Early Treatment. Change from baseline to 18 months on the modified Alzheimer's Prevention Cognitive Composite (primary outcome) was compared against matched historical control cohorts. Cognitive aging composite (CogAging), AD/cardiovascular risk scales, and serum biomarkers were secondary outcomes.

Results

One hundred seventy-four were assigned interventions (age 25-

SUBMITTER: Isaacson RS 

PROVIDER: S-EPMC6925647 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature