Achieved oxygen saturations and retinopathy of prematurity in extreme preterms.

ABSTRACT:

Objective

To identify achieved oxygen saturations (SpO₂) associated with increased risk of severe retinopathy of prematurity (ROP).

Design

This is a secondary analysis of the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT)randomised controlled trial. SpO₂ was recorded up to 36 weeks' postmenstrual age. Saturations through 9 postnatal weeks were explored graphically, and logistic regression models were created to predict severe ROP.

Setting

20 centres of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

Patients

984 surviving infants of 24-27 weeks' gestational age born in 2005-2009.

Interventions

SUPPORT targeted SpO₂ to a lower (85

SUBMITTER: Gantz MG 

PROVIDER: S-EPMC6925651 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature