Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional outcome after stroke.

ABSTRACT: The development of new therapeutic approaches for stroke patients requires a detailed understanding of the mechanisms that enhance recovery of lost neurological functions. The efficacy to enhance homeostatic mechanisms during the first weeks after stroke will influence functional outcome. Thyroid hormones (TH) are essential regulators of neuronal plasticity, however, their role in recovery related mechanisms of neuronal plasticity after stroke remains unknown. This study addresses important findings of 3,5,3'-triiodo-L-thyronine (T₃) in the regulation of homeostatic mechanisms that adjust excitability - inhibition ratio in the post-ischemic brain. This is valid during the first 2 weeks after experimental stroke induced by photothrombosis (PT) and in cultured neurons subjected to

SUBMITTER: Talhada D 

PROVIDER: S-EPMC6925884 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature