Alcohol shifts gut microbial networks and ameliorates a murine model of neuroinflammation in a sex-specific pattern.

ABSTRACT: Alcohol is a widely consumed dietary component by patients with autoimmune neuroinflammatory diseases, but current evidence on the effects of alcohol in these conditions is confounding. Epidemiological studies suggest moderate consumption of alcohol may be protective in some autoimmune diseases; however, this correlation has not been directly investigated. Here, we characterize the effects of moderate-dose alcohol in a model system of autoimmune neuroinflammation, experimental autoimmune encephalomyelitis (EAE). Male and female C57BL/6J mice were fed a 2.6% alcohol or isocaloric diet for 3 wk prior to MOG_35-55 EAE induction. Surprisingly, alcohol-fed males experienced significantly greater disease remission compared to alcohol-fed females and control-fed counterparts. We observe

SUBMITTER: Caslin B 

PROVIDER: S-EPMC6925977 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature