B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells.

ABSTRACT: The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4⁺ T cells. It is not known if naive B cells spontaneously display pId:MHCII in vivo or if BCR ligation is required for expression, thereby enabling collaboration between Id⁺ B cells and Id-specific T cells. Here, using a mouse model, we show that naive B cells do not express readily detectable levels of pId:MHCII. However, BCR ligation by Ag dramatically increases physical display of pId:MHCII, leading to activation of Id-specific CD4⁺ T cells, extrafollicular T-B cell collaboration and some germinal ce

SUBMITTER: Huszthy PC 

PROVIDER: S-EPMC6926052 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature