Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces.

ABSTRACT: The interface between water and folded proteins is very complex. Proteins have "patchy" solvent-accessible areas composed of domains of varying hydrophobicity. The textbook understanding is that these domains contribute additively to interfacial properties (Cassie's equation, CE). An ever-growing number of modeling papers question the validity of CE at molecular length scales, but there is no conclusive experiment to support this and no proposed new theoretical framework. Here, we study the wetting of model compounds with patchy surfaces differing solely in patchiness but not in composition. Were CE to be correct, these materials would have had the same solid-liquid work of adhesion (W_SL ) and time-averaged structure of interfacial water. We find considerable diffe

SUBMITTER: Luo Z 

PROVIDER: S-EPMC6926055 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature