Sustaining exposure to high concentrations of bifidobacteria inhibits gene expression of Mouse's mucosal immunity.

ABSTRACT: Numerous dietary products are supplemented with probiotics that may be beneficial for human health. Recently, bifidobacteria have received increasing attention as a genus of probiotic bacteria with high efficiency and few side effects. To examine potential effects of different bifidobacteria concentrations on the mucosal immune response, we fed mice with (a) 108 colony-forming units (CFU) of bifidobacteria (group 108 B), and (b) with 1012 CFU of bifidobacteria (group 1012 B) over 42 days and assessed gene expression in intestinal mucosa and immune marker concentrations in serum samples; ten untreated female mice were used as a control. Continuous exposure to 108 CFU of bifidobacteria activated both macrophages and Treg immune cells through significantly increasing the expression of mucosal

SUBMITTER: El Hadad S 

PROVIDER: S-EPMC6926234 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature