Childhood and Adolescent Nonalcoholic Fatty Liver Disease: Is It Different from Adults?

ABSTRACT: Paediatric nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in childhood and adolescence. Although the condition is similar in many ways to NAFLD in adults, there are important differences in predisposition, presentation, differential diagnosis and potentially also in optimal management. Antenatal and early childhood exposures and the particular vulnerabilities to environmental influences in a growing child, present unique opportunities for intervention and modification of risk. The prevalence of significant fibrosis on biopsy in preadolescent children in the context of NAFLD should not be ignored, but the relevance of this fibrosis to long-term outcome is as yet unknown. The approach to children and adolescents with suspected NAFLD needs to include an asse

SUBMITTER: Fitzpatrick E 

PROVIDER: S-EPMC6926239 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature