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Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control.

ABSTRACT: Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.

SUBMITTER: Nazni WA 

PROVIDER: S-EPMC6926472 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control.

Nazni Wasi A WA   Hoffmann Ary A AA   NoorAfizah Ahmad A   Cheong Yoon Ling YL   Mancini Maria V MV   Golding Nicholas N   Kamarul Ghazali M R GMR   Arif Mohd A K MAK   Thohir Hasim H   NurSyamimi Halim H   ZatilAqmar M Zabari MZ   NurRuqqayah Mazni M   NorSyazwani Amran A   Faiz Azmi A   Irfan Francis-Rudin M N FMN   Rubaaini Subramaniam S   Nuradila Nasir N   Nizam Nasir M N NMN   Irwan Saidin M SM   Endersby-Harshman Nancy M NM   White Vanessa L VL   Ant Thomas H TH   Herd Christie S CS   Hasnor Asim H AH   AbuBakar Rahman R   Hapsah Dusa M DM   Khadijah Khairuddin K   Kamilan Denim D   Lee Soo Cheng SC   Paid Yusof M YM   Fadzilah Kamaludin K   Topek Omar O   Gill Balvinder S BS   Lee Han Lim HL   Sinkins Steven P SP  

Current biology : CB 20191121 24

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB wer  ...[more]