VIO: ontology classification and study of vaccine responses given various experimental and analytical conditions.

ABSTRACT:

Background

Different human responses to the same vaccine were frequently observed. For example, independent studies identified overlapping but different transcriptomic gene expression profiles in Yellow Fever vaccine 17D (YF-17D) immunized human subjects. Different experimental and analysis conditions were likely contributed to the observed differences. To investigate this issue, we developed a Vaccine Investigation Ontology (VIO), and applied VIO to classify the different variables and relations among these variables systematically. We then evaluated whether the ontological VIO modeling and VIO-based statistical analysis would contribute to the enhanced vaccine investigation studies and a better understanding of vaccine response mechanisms.

Results

Our VIO modeling identifi

SUBMITTER: Ong E 

PROVIDER: S-EPMC6927110 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature