Genome-wide association study of multiplex schizophrenia pedigrees.

ABSTRACT:

Objective

The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs).

Method

The family sample included 2,461 individuals from 631 pedigrees (581 in the primary European-ancestry analyses). Association was tested for single SNPs and genetic pathways. Polygenic scores based on family study results were used to predict case-control status in the Schizophrenia Psychiatric GWAS Consortium (PGC) data set, and consistency of direction of effect with the family study was determined for top SNPs in the PGC GWAS analysis. Within-family segregation was examined for schizophrenia-associated rare CNVs.

Results

No genome-w

SUBMITTER: Levinson DF 

PROVIDER: S-EPMC6927206 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature