Expression of BSP-GFPtpz Transgene during Osteogenesis and Reparative Dentinogenesis.

ABSTRACT: Bone sialoprotein (BSP) is a member of the SIBLING family with essential roles in skeletogenesis. In the developing teeth, although the expression and function of BSP in the formation of acellular cementum and periodontal attachment are well documented, there are uncertainties regarding the expression and function of BSP by odontoblasts and dentin. Reporter mice are valuable animal models for biological research, providing a gene expression readout that can contribute to cellular characterization within the context of a developmental process. In the present study, we examined the expression of a BSP-GFPtpz reporter mouse line during odontoblast differentiation, reparative dentinogenesis, and bone. In the developing teeth, BSP-GFPtpz was expressed at high levels in cementoblasts but not in

SUBMITTER: Vijaykumar A 

PROVIDER: S-EPMC6927219 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature