The Effect of Initial High vs. Low FiO₂ on Breathing Effort in Preterm Infants at Birth: A Randomized Controlled Trial.

ABSTRACT: Background: Infants are currently stabilized at birth with initial low FiO₂ which increases the risk of hypoxia and suppression of breathing in the first minutes after birth. We hypothesized that initiating stabilization at birth with a high O₂ concentration, followed by titration, would improve breathing effort when compared to a low O₂ concentration, followed by titration. Methods: In a bi-center randomized controlled trial, infants <30 weeks gestation were stabilized at birth with an initial O₂ concentration of 30 or 100%, followed by oxygen titration. Primary outcome was minute volume of spontaneous breathing. We also assessed tidal volumes, mean inspiratory flow rate (MIFR) and respiratory rate with a respiratory function monit

SUBMITTER: Dekker J 

PROVIDER: S-EPMC6927294 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature