Thermal Sensitive Liposomes Improve Delivery of Boronated Agents for Boron Neutron Capture Therapy.

ABSTRACT:

Purpose

Boron neutron capture therapy (BNCT) has the potential to become a viable cancer treatment modality, but its clinical translation requires sufficient tumor boron delivery while minimizing nonspecific accumulation.

Methods

Thermal sensitive liposomes (TSLs) were designed to have a stable drug payload at physiological temperatures but engineered to have high permeability under mild hyperthermia.

Results

We found that TSLs improved the tumor-specific delivery of boronophenylalanine (BPA) and boronated 2-nitroimidazole derivative B-381 in D54 glioma cells. Uniquely, the 2-nitroimidazole moiety extended the tumor retention of boron content compared to BPA.

Conclusion

This is the first study to show the delivery of boronated compounds using TSLs for BNCT, and

SUBMITTER: Luderer MJ 

PROVIDER: S-EPMC6927330 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature