Perceived neighborhood social cohesion and cardiometabolic risk: a gene × environment study.

ABSTRACT: People living in socially cohesive neighborhoods generally have better health. We extend this research by evaluating the hypothesis that perceived neighborhood cohesion may influence health by attenuating genetic liability for cardiometabolic risk factors. Using data from the Health and Retirement Study (n = 6,615; mean age 69.7), we conducted a gene × environment interaction study hypothesizing that perceived neighborhood cohesion would attenuate the link between polygenic scores for waist-to-hip ratio (WHR) and body mass index and a measure of multisystem cardiometabolic risk (systolic blood pressure [SBP] and diastolic blood pressure [DBP], heart rate, A1c, C-reactive protein, and total and high-density lipoprotein cholesterol). In support of the hypothesis, results indicated tha

SUBMITTER: Robinette JW 

PROVIDER: S-EPMC6927540 | biostudies-literature | 2018 Jul-Sep

REPOSITORIES: biostudies-literature