Cost effectiveness of therapeutic drug monitoring for imatinib administration in chronic myeloid leukemia.

ABSTRACT:

Background

Imatinib mesylate (IM) is a first-line treatment option for patients with chronic myeloid leukemia (CML). Patients who fail or are intolerant to IM therapy are treated with more expensive second and third-generation tyrosine kinase inhibitors. Patients show wide variation in trough concentrations in response to standard dosing. Thus, many patients receive subtherapeutic or supratherapeutic doses. Therapeutic drug monitoring (TDM) may improve dose management that, in turn, may reduce costs and improve outcomes. However, TDM also adds to the cost of patient care. The objective of this study was to determine the cost-effectiveness of TDM for generic IM therapy.

Methods

We developed a microsimulation model for the trough plasma concentration of IM which is related to

SUBMITTER: Kim K 

PROVIDER: S-EPMC6927594 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature