Molecular Control of Phosphorus Homeostasis and Precision Treatment of Hypophosphatemic Disorders.

ABSTRACT:

Purpose of review

Serum phosphorus is maintained in a narrow range by balancing dietary phosphate absorption, influx and efflux of phosphorus from bone and intracellular stores, and renal reabsorption of filtered phosphate. Acute hypophosphatemia, typically caused by transient increases in cellular uptake, can lead to severe complications such as cardiopulmonary dysfunction and rhabdomyolysis that can warrant parenteral phosphate repletion. Chronic hypophosphatemia, however, generally represents true phosphate deficiency and may result in long-term metabolic and skeletal complications, particularly in children due to the critical importance of phosphorus to skeletal mineralization and longitudinal growth.

Recent findings

In addition to the well characterized roles of vitamin

SUBMITTER: Weber TJ 

PROVIDER: S-EPMC6927676 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature