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Harnessing MerTK agonism for targeted therapeutics.

ABSTRACT: Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically silent. Here, we describe a bispecific antibody approach to harness MerTK for targeted clearance without inducing proinflammatory cytokine release associated with Fcγ receptor engagement. We generated bispecific antibodies targeting live B cells or amyloid beta aggregates to demonstrate the feasibility and versatility of this new approach.

SUBMITTER: Kedage V

PROVIDER: S-EPMC6927767 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature

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Harnessing MerTK agonism for targeted therapeutics.

Kedage Vivekananda V Ellerman Diego D Chen Yongmei Y Liang Wei-Ching WC Borneo Joven J Wu Yan Y Yan Minhong M

mAbs 20200101 1

Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically silent. Here, we describe a bispecific antibody approach to harness MerTK for targeted clearance without inducing proinflammatory cytokine release associated with Fcγ receptor engagement. We generated bi ...[more]

PMID: 31852344

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