Activation of Peripheral T Follicular Helper Cells During Acute Dengue Virus Infection.

ABSTRACT:

Background

Follicular helper T cells (TFH) are specialized CD4 T cells required for B-cell help and antibody production.

Methods

Given the postulated role of immune activation in dengue disease, we measured the expansion and activation of TFH in the circulation (peripheral TFH [pTFH]) collected from Thai children with laboratory-confirmed acute dengue virus (DENV) infection.

Results

We found significant expansion and activation of pTFH subsets during acute infection with the highest frequencies of activated pTFH (PD1hi pTFH and PD1+CD38+ pTFH) detected during the critical phase of illness. Numbers of activated pTFH were higher in patients with secondary compared with primary infections and in patients with more severe disease. We also found a positive correlation betw

SUBMITTER: Haltaufderhyde K 

PROVIDER: S-EPMC6927865 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature