Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants.

ABSTRACT:

Objectives

Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed. We sought to better understand the effect of prophylactic fluconazole on a selection of fluconazole-resistant Candida species.

Methods

We evaluated the susceptibility to fluconazole of Candida isolates from premature infants (<750 g birth weight) enrolled in a multicentre, randomized, placebo-controlled trial of fluconazole prophylaxis. Candida species were isolated through surveillance cultures at baseline (study day 0-7), period 1 (study day 8-28) and period 2 (study day 29-49). Fluconazole MICs were determined for all Candida isolates.

Results

Three

SUBMITTER: Autmizguine J 

PROVIDER: S-EPMC6927883 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature