Meta-Analysis of Pharmacokinetic Studies of Nanobiomaterials for the Prediction of Excretion Depending on Particle Characteristics.

ABSTRACT: The growth in development and use of nanobiomaterials (NBMs) has raised questions regarding their possible distribution in the environment. Because most NBMs are not yet available on the market and exposure monitoring is thus not possible, prospective exposure modeling is the method of choice to get information on their future environmental exposure. An important input for such models is the fraction of the NBM excreted after their application to humans. The aim of this study was to analyze the current literature on excretion of NBMs using a meta-analysis. Published pharmacokinetic data from in vivo animal experiments was collected and compiled in a database, including information on the material characteristics. An evaluation of the data showed that there is no correlation between the exc

SUBMITTER: Hauser M 

PROVIDER: S-EPMC6927930 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature