Terminal neuron localization to the upper cortical plate is controlled by the transcription factor NEUROD2.

ABSTRACT: Excitatory neurons of the mammalian cerebral cortex are organized into six functional layers characterized by unique patterns of connectivity, as well as distinctive physiological and morphological properties. Cortical layers appear after a highly regulated migration process in which cells move from the deeper, proliferative zone toward the superficial layers. Importantly, defects in this radial migration process have been implicated in neurodevelopmental and psychiatric diseases. Here we report that during the final stages of migration, transcription factor Neurogenic Differentiation 2 (Neurod2) contributes to terminal cellular localization within the cortical plate. In mice, in utero knockdown of Neurod2 resulted in reduced numbers of neurons localized to the uppermost region of the deve

SUBMITTER: Guzelsoy G 

PROVIDER: S-EPMC6927953 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature