Postoperative Radiotherapy Improves Survival in Gastric Signet-Ring Cell Carcinoma: a SEER Database Analysis.

ABSTRACT:

Purpose

To identify the potential therapeutic role of postoperative radiotherapy (RT) in patients with locally advanced (stage II and stage III) gastric signet ring cell carcinoma (SRC).

Materials and methods

Patients with locally advanced gastric SRC from the Surveillance, Epidemiology, and End Results program database between 2004 and 2012 were included in our study. Univariate and multivariate Cox proportional models were performed, and survival curves were generated to evaluate the prognostic effect of postoperative RT and surgery alone on SRC patients. Propensity score matching (PSM) was used to avoid selection bias among the study cohorts.

Results

We found that patients with postoperative RT had better probability of survival compared with those who did not rece

SUBMITTER: Wei F 

PROVIDER: S-EPMC6928086 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature