Molecular dynamics simulation of the nanosecond pulsed electric field effect on kinesin nanomotor.

ABSTRACT: Kinesin is a biological molecular nanomotor which converts chemical energy into mechanical work. To fulfill various nanotechnological tasks in engineered environments, the function of biological molecular motors can be altered by artificial chemical modifications. The drawback of this approach is the necessity of designing and creating a new motor construct for every new task. We propose that intense nanosecond-scale pulsed electric field could modify the function of nanomotors. To explore this hypothesis, we performed molecular dynamics simulation of a kinesin motor domain docked on a subunit of its microtubule track - a single tubulin heterodimer. In the simulation, we exposed the kinesin motor domain to intense (100 MV/m) electric field up to 30 ns. We found that both the magnitude and

SUBMITTER: Prusa J 

PROVIDER: S-EPMC6928163 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature