Vitamin D release across abdominal adipose tissue in lean and obese men: The effect of ß-adrenergic stimulation.

ABSTRACT: Obesity is characterized by a blunted lipolytic response in abdominal subcutaneous adipose tissue (SAT) and low circulating vitamin D levels. Here we investigated whether an impaired SAT lipolytic response coincides with an impaired SAT vitamin D release in eight lean and six obese men. 25-hydroxyvitamin D₃ [25(OH)D₃ ] and 1,25-dihydroxyvitamin D₃ [1,25(OH)₂ D₃ ] fluxes across SAT were measured using arterio-venous blood sampling in combination with AT blood flow measurements after an overnight fast and during 1-hr intravenous infusion of the non-selective ß-adrenergic agonist isoprenaline (20 ng·kg FFM^-1 ·min^-1 ). 1,25(OH)₂ D₃ was released across abdominal SAT during isoprenaline infusion in

SUBMITTER: Pramono A 

PROVIDER: S-EPMC6928243 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature