Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle.

ABSTRACT: Skeletal muscle (SKM) requires a large amount of energy, which is produced mainly by mitochondria, for their daily functioning. Of the several mitochondrial complexes, it has been reported that the dysfunction of complex II is associated with several diseases, including myopathy. However, the degree to which complex II contributes to ATP production by mitochondria remains unknown. As complex II is not included in supercomplexes, which are formed to produce ATP efficiently, we hypothesized that complex II-linked respiration was lower than that of complex I. In addition, differences in the characteristics of complex I and II activity suggest that different factors might regulate their function. The isolated mitochondria from gastrocnemius muscle was used for mitochondrial respiration measure

SUBMITTER: Maekawa S 

PROVIDER: S-EPMC6928343 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature