An Atmosphere-Breathing Refillable Biphasic Device for Cell Replacement Therapy.

ABSTRACT: Cell replacement therapy is emerging as a promising treatment platform for many endocrine disorders and hormone deficiency diseases. The survival of cells within delivery devices is, however, often limited due to low oxygen levels in common transplantation sites. Additionally, replacing implanted devices at the end of the graft lifetime is often unfeasible and, where possible, generally requires invasive surgical procedures. Here, the design and testing of a modular transcutaneous biphasic (BP) cell delivery device that provides enhanced and unlimited oxygen supply by direct contact with the atmosphere is presented. Critically, the cell delivery unit is demountable from the fixed components of the device, allowing for surgery-free refilling of the therapeutic cells. Mass transfer studies s

SUBMITTER: An D 

PROVIDER: S-EPMC6928421 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature