Characterization of a highly effective preparation for suppression of myocardial glucose utilization.

ABSTRACT:

Background

With appropriate protocols, F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can visualize myocardial inflammation. Optimal protocols and normative myocardial FDG uptake values are not well-established.

Methods

We evaluated 111 patients referred for inflammation cardiac FDG PET/CT. Patients followed a low-carbohydrate, high-fat diet for 36 hours before imaging and received unfractionated heparin. Glucose and fatty acid metabolism biomarkers were obtained. Mean blood pool and maximum myocardial uptake (SUV_mean, SUV_max) were measured, avoiding areas of abnormal FDG uptake or spillover.

Results

Adequate suppression of myocardial FDG uptake occurred in 95% of patients (n = 106). Myocardial SUV_max

SUBMITTER: Larson SR 

PROVIDER: S-EPMC6928445 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature