Clinical characteristics of colitis induced by taxane-based chemotherapy.

ABSTRACT:

Background

Limited data are available concerning the clinical features of toxic gastrointestinal (GI) effects of taxane-based therapy. We describe the clinical, endoscopic and histologic features of taxane-induced colitis.

Methods

This retrospective study included cancer patients who received taxane therapy and underwent colonoscopy for GI symptoms from 2000-2018.

Results

Of the 45,527 patients who received taxane therapy during the study period, 76 (0.2%) met the inclusion criteria. Most patients (54%) received paclitaxel, 37% docetaxel, and 9% nab-paclitaxel. The median time from taxane therapy initiation to colitis symptom onset was 31 days. The median duration of colitis symptoms was 30 days. Colitis treatment comprised immunosuppressive therapy in 8 patients (11%

SUBMITTER: Chen E 

PROVIDER: S-EPMC6928479 | biostudies-literature | 2020 Jan-Feb

REPOSITORIES: biostudies-literature