Divergent metabolic substrate utilization in brain during epileptogenesis precedes chronic hypometabolism.

ABSTRACT: Alterations in metabolism during epileptogenesis may be a therapy target. Recently, an increase in amino acid transport into the brain was proposed to play a role in epileptogenesis. We aimed to characterize alterations of substrate utilization during epileptogenesis and in chronic epilepsy. The lithium-pilocarpine post status epilepticus (SE) rat model was used. We performed longitudinal O-(2-[(18)F]fluoroethyl)-l-tyrosine (¹⁸F-FET) and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) and calculated ¹⁸F-FET volume of distribution (V_t) and ¹⁸F-FDG uptake. Correlation analyses were performed with translocator protein-PET defined neuroinflammation from previously acquired data. We found reduced ¹⁸

SUBMITTER: Bascunana P 

PROVIDER: S-EPMC6928550 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature