The longitudinal relationship between changes in wellbeing and inflammatory markers: Are associations independent of depression?

ABSTRACT:

Objectives

There is a large literature linking inflammation with mental ill health, but a much smaller literature focusing on mental wellbeing. Specifically, it remains unclear whether mental wellbeing is longitudinally and independently associated with inflammation or only via associated changes in mental ill health.

Methods

This study used data from 8780 adults aged 50+ in the English Longitudinal Study of Ageing. Hedonic wellbeing (both positive affect and life satisfaction) and eudemonic wellbeing (self-realisation and control-autonomy) were measured at data collection waves 2 (2004/05), 4 (2008/09) and 6 (20012/13), along with measures of C-reactive protein (CRP), fibrinogen and white blood cells (WBC). Fixed effects modelling was performed to identify the longitudinal

SUBMITTER: Fancourt D 

PROVIDER: S-EPMC6928572 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature