TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung.

ABSTRACT:

Background

In the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell types that support the structure of the developing and mature organ. Whether the embryonic pulmonary mesenchyme is a homogenous precursor pool and how it diversifies into different cell lineages is poorly understood. We have previously shown that the T-box transcription factor gene Tbx2 is expressed in the pulmonary mesenchyme of the developing murine lung and is required therein to maintain branching morphogenesis.

Methods

We determined Tbx2/TBX2 expression in the developing murine lung by in situ hybridization and immunofluorescence analyses. We used a genetic

SUBMITTER: Wojahn I 

PROVIDER: S-EPMC6929292 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature