Typing of hereditary renal amyloidosis presenting with isolated glomerular amyloid deposition.

ABSTRACT:

Background

The commonly used methods for amyloid typing include immunofluorescence or immunohistochemistry (IHC), which sometimes may come with diagnostic pitfalls. Mass spectrometry (MS)-based proteomics has been recognized as a reliable technique in amyloid typing.

Case presentation

We reported two middle-aged patients who presented with proteinuria, hypertension and normal renal function, and both had a family history of renal diseases. The renal biopsies of both patients revealed renal amyloidosis with the similar pattern by massive exclusively glomerular amyloid deposition. The IHC was performed by using a panel of antibodies against the common types of systemic amyloidosis, and demonstrated co-deposition of fibrinogen Aα chain and apolipoprotein A-I in the glomerular a

SUBMITTER: Li D 

PROVIDER: S-EPMC6929319 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature